01.05.15
Source: Clinical Nutrition, October 2014
Research: Dyslipidemia is a risk factor for cardiovascular disease that has become an increasing public health problem. Dyslipidemia is especially relevant in vulnerable populations such as postmenopausal women. Low serum levels of 25-hydroxyvitamin D have been associated with an unfavorable lipid profile. Due to contradictory findings from intervention trials, researchers investigated the effect of vitamin D supplementation on serum lipids in postmenopausal women with type 2 diabetes. A total of 104 postmenopausal women with type 2 diabetes were randomly assigned in a double-blind manner to receive either 4,000 IU of vitamin D daily for 6 months (n = 52) or placebo (n = 52).
Results: The study was completed by 99 participants. However, as the analysis was based on an intention-to-treat approach, all 104 women were included in the final analysis. In the vitamin D group, mean serum levels of 25(OH)D3 improved significantly at the end of the follow-up period (+25.5 nmol/L; P = <0.001). Findings revealed no significant changes in low density lipoproteins, high density lipoproteins and total cholesterol concentrations, but did identify a greater decrease in serum triglycerides in the vitamin D group.
The average effect of supplementation on the treated group was −34.24 mg/dL (P = 0.021), while the average treatment effect was −31.8 mg/dL (P = 0.023). Researchers concluded that results suggest supplementation with vitamin D (4,000 IU/d) may have a beneficial effect on serum triglyceride levels without otherwise affecting levels of other lipids.
Research: Dyslipidemia is a risk factor for cardiovascular disease that has become an increasing public health problem. Dyslipidemia is especially relevant in vulnerable populations such as postmenopausal women. Low serum levels of 25-hydroxyvitamin D have been associated with an unfavorable lipid profile. Due to contradictory findings from intervention trials, researchers investigated the effect of vitamin D supplementation on serum lipids in postmenopausal women with type 2 diabetes. A total of 104 postmenopausal women with type 2 diabetes were randomly assigned in a double-blind manner to receive either 4,000 IU of vitamin D daily for 6 months (n = 52) or placebo (n = 52).
Results: The study was completed by 99 participants. However, as the analysis was based on an intention-to-treat approach, all 104 women were included in the final analysis. In the vitamin D group, mean serum levels of 25(OH)D3 improved significantly at the end of the follow-up period (+25.5 nmol/L; P = <0.001). Findings revealed no significant changes in low density lipoproteins, high density lipoproteins and total cholesterol concentrations, but did identify a greater decrease in serum triglycerides in the vitamin D group.
The average effect of supplementation on the treated group was −34.24 mg/dL (P = 0.021), while the average treatment effect was −31.8 mg/dL (P = 0.023). Researchers concluded that results suggest supplementation with vitamin D (4,000 IU/d) may have a beneficial effect on serum triglyceride levels without otherwise affecting levels of other lipids.
